Mice may be ubiquitous in the modern computer world, but that doesn't make them the best choice for all activities. Aside from being difficult to use for precise graphics editing, mice can lead to or aggravate repetitive strain injuries (RSIs) - something to avoid at all cost.
Wacom graphics tablets provide a great alternative input device, and even if you don't spend all day editing in Photoshop they're well suited for mousing around as well. Another often overlooked benefit of using a pen based input device is Apple's built in Inkwell handwriting recognition technology. Inkwell allows you to write entire sentences on your tablet and have them translated to text just as if you were typing.
On the down side, clicking small targets is sometimes difficult since the pen is very sensitive and you may end up dragging rather than clicking. Also, the tablet doesn't play well with the previously reviewed Control Scroll Zoom; when zoomed, tablet clicks are offset and don't land where they should. It is unclear whether this is a problem with OS X or with Wacom's drivers. A tablet probably isn't a 100% replacement for a normal mouse or trackpad, but when used in conjunction with traditional devices (or even the included mouse), it works very well.
The Graphire wireless tablet comes with a stylus, stylus holder, two button scroll mouse, and recharging cable. Wacom's technology doesn't require a battery in the stylus, so it's very light weight and easy to use. In addition to being pressure sensitive (with applicable programs like Photoshop), the stylus and the tablet itself both have two programmable buttons on them which can be configured with Wacom's System Preference Pane.
For best results with Inkwell, try using "mouse mode" and turning "mouse acceleration" off. Also, make sure to download and install the newest drivers from Wacom as the ones included on the CD have problems with lag time.